Format

Send to

Choose Destination
See comment in PubMed Commons below
J Mater Sci Mater Med. 2008 Feb;19(2):847-54. Epub 2007 Aug 1.

Electrospun nanofibers immobilized with collagen for neural stem cells culture.

Author information

1
Department of Neurosurgery, 3rd Affiliated Hospital of SUN YAT-SEN University, Guangzhou, P.R. China.

Abstract

Fibrous mats via electrospinning have been widely applied in tissue engineering. In this work, nanofibers were prepared via electrospinning from polymer with different content of carboxyl groups. A natural material, collagen, was then immobilized onto the nanofiber surface by N-(3-dimethylaminopropyl)-N'-ethylcarbodiimide hydrochloride (EDC)/N-Hydroxysuccinimide (NHS) activation process. It was found that the immobilization degree of collagen could be facilely modulated. The obtained collagen-modified nanofibers were used for neural stem cells culture, and unmodified nanofibers were used as a control. Results indicated that the modification of collagen could enhance the attachment and viability of the cultured neural stem cells.

PMID:
17665116
DOI:
10.1007/s10856-007-3087-5
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Springer
    Loading ...
    Support Center