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Prim Care Respir J. 2007 Aug;16(4):236-40.

The relationship between inflammatory markers and disability in chronic obstructive pulmonary disease (COPD).

Author information

1
School of Physiotherapy, St Georges Hospital, University of London, London, UK. garrod@hscs.sgul.ac.uk

Abstract

AIMS:

To examine relationships between markers of systemic inflammation and functional status in patients with chronic obstructive pulmonary disease (COPD).

METHODS:

41 COPD patients were stratified using the Medical Research Council (MRC) dyspnoea scale. Six-minute walking distance (6MWD), Quadriceps (% body weight) (QBW), St George's Hospital Respiratory Questionnaire (SGRQ), London Chest Activity of Daily Living Scale (LCADL), C-reactive protein (CRP), interleukin 6 (IL6), tumour necrosis factor alpha, and neopterin were measured. Relationships between variables and differences in inflammatory markers between MRC categories were tested.

RESULTS:

Inflammation increased with MRC grade and was significantly different across grades; CRP (p=0.002) and IL6 (p=0.04). Relationships were evident between CRP, 6MWD, LCADL and SGRQ, r=-0.47, 0.50, 0.43 (all p<0.01) respectively, and between IL6, QBW and LCADL, rho=-0.36, 0.51 (p<0.05).

CONCLUSIONS:

Measures of systemic inflammation, and in particular CRP, may prove to be useful markers in the assessment of COPD severity in primary care.

PMID:
17665081
PMCID:
PMC6634218
DOI:
10.3132/pcrj.2007.00047
[Indexed for MEDLINE]
Free PMC Article

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