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J Neurosci Res. 2008 Jan;86(1):1-10.

Metabotropic glutamate receptors: phosphorylation and receptor signaling.

Author information

1
Department of Pharmacology, Brain Research Institute, Brain Korea 21 Project for Medical Science, Yonsei University College of Medicine, Seoul, Korea. kimhoon@yuhs.ac

Abstract

Metabotropic glutamate receptors (mGluRs) play important roles in neurotransmission, neuronal development, synaptic plasticity, and neurological disorders. Recent studies have revealed a sophisticated interplay between mGluRs and protein kinases: activation of mGluRs regulates the activity of a number of kinases, and direct phosphorylation of mGluRs affects receptor signaling, trafficking, and desensitization. Here we review the emerging literature on mGluR phosphorylation, signaling, and synaptic function.

PMID:
17663464
DOI:
10.1002/jnr.21437
[Indexed for MEDLINE]

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