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Cell. 2007 Jul 27;130(2):211-3.

Mitochondrial DNA transcription: regulating the power supply.

Author information

1
Mitochondrial Research Group, School of Neurology, Neurobiology and Psychiatry, The Medical School, Newcastle University, Newcastle upon Tyne, UK.

Abstract

In this issue of Cell, Park et al. (2007) describe the nuclear encoded protein MTERF3 as a negative regulator of mitochondrial DNA transcription initiation. This study highlights a mechanism by which mitochondrial DNA transcription (and therefore oxidative phosphorylation) may be regulated in response to alterations in the cell's physiological and metabolic demands.

PMID:
17662933
DOI:
10.1016/j.cell.2007.07.002
[Indexed for MEDLINE]
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