Mitochondrial DNA transcription: regulating the power supply

Cell. 2007 Jul 27;130(2):211-3. doi: 10.1016/j.cell.2007.07.002.

Abstract

In this issue of Cell, Park et al. (2007) describe the nuclear encoded protein MTERF3 as a negative regulator of mitochondrial DNA transcription initiation. This study highlights a mechanism by which mitochondrial DNA transcription (and therefore oxidative phosphorylation) may be regulated in response to alterations in the cell's physiological and metabolic demands.

Publication types

  • Comment
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • DNA, Mitochondrial / genetics*
  • Mice
  • Mice, Knockout
  • Mitochondria / pathology
  • Mitochondrial Proteins / metabolism
  • Myocardium / pathology
  • Myocardium / ultrastructure
  • Organ Specificity
  • Transcription, Genetic*

Substances

  • DNA, Mitochondrial
  • Mitochondrial Proteins