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Biochem Biophys Res Commun. 2007 Sep 21;361(2):555-60. Epub 2007 Jul 23.

The Hd0053 gene of Haemophilus ducreyi encodes an alpha2,3-sialyltransferase.

Author information

1
Department of Chemistry, University of California, One Shields Avenue, Davis, CA 95616, USA.

Abstract

Haemophilus ducreyi is a Gram-negative bacterium that causes chancroid, a sexually transmitted genital ulcer disease. Different lipooligosaccharide (LOS) structures have been identified from H. ducreyi strain 35000, including those sialylated glycoforms. Surface LOS of H. ducreyi is considered an important virulence factor that is involved in ulcer formation, cell adhesion, and invasion of host tissue. Gene Hd0686 of H. ducreyi, designated lst (for lipooligosaccharide sialyltransferase), was identified to encode an alpha2,3-sialyltransferase that is important for the formation of sialylated LOS. Here, we show that Hd0053 of H. ducreyi genomic strain 35000HP, the third member of the glycosyltransferase family 80 (GT80), also encodes an alpha2,3-sialyltransferase that may be important for LOS sialylation.

PMID:
17662691
PMCID:
PMC2084346
DOI:
10.1016/j.bbrc.2007.07.063
[Indexed for MEDLINE]
Free PMC Article

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