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Trends Parasitol. 2007 Sep;23(9):450-7. Epub 2007 Jul 26.

Tick cell lines: tools for tick and tick-borne disease research.

Author information

1
Centre for Tropical Veterinary Medicine, Royal (Dick) School of Veterinary Studies, University of Edinburgh, Easter Bush Veterinary Centre, Roslin, Midlothian EH25 9RG, UK. L.Sakyi@ed.ac.uk

Abstract

Over 40 cell lines are currently available from 13 ixodid and one argasid tick species. The successful isolation and propagation of several economically important tick-borne pathogens in tick cell lines has created a useful model to study interactions between tick cells and these viral and bacterial disease agents. Tick cell lines have already proved to be a useful tool in helping to define the complex nature of the host-vector-pathogen relationship. With the availability of genomics tools, tick cell lines will become increasingly important as a complement to tick and tick-borne disease research in vivo once genetic transformation and gene silencing using RNA interference become routine.

PMID:
17662657
DOI:
10.1016/j.pt.2007.07.009
[Indexed for MEDLINE]

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