Format

Send to

Choose Destination
Dermatol Surg. 2007 Aug;33(8):928-36.

A randomized, evaluator-blinded comparison of efficacy of hyaluronic acid gel and avian-sourced hylan B plus gel for correction of nasolabial folds.

Author information

1
Palm Beach Esthetic Center, West Palm Beach, Florida 33401-2717, USA. kenbeer@aol.com

Abstract

BACKGROUND:

Five hyaluronic acid (HA)-based, biodegradable dermal fillers are approved by the U.S. Food and Drug Administration for the correction of moderate to severe facial wrinkles and folds. Because satisfactory initial correction can be obtained with all these agents, duration of cosmetic correction is an important distinguishing characteristic.

OBJECTIVE:

The objective was to compare the efficacy and duration of treatment effects of HA gel and hylan B plus gel for the cosmetic correction of nasolabial folds.

METHODS:

Fifteen patients with prominent nasolabial folds were randomized to treatment with HA gel and hylan B plus gel on contralateral sides of the face. Wrinkle severity and global aesthetic improvement were assessed by patients and a blinded evaluating investigator. Wrinkle Severity Rating Scale scores and Global Aesthetic Improvement Scale scores on both facial sides were assessed 2 weeks, 3 months, 4.5 months, and 6 months after treatment.

RESULTS:

Wrinkle Severity Rating Scale scores and Global Aesthetic Improvement Scale scores were significantly higher for HA gel at 3, 4.5, and 6 months as assessed by both patients and evaluating investigator.

CONCLUSION:

Both HA gel and hylan B plus gel provide dermal augmentation of nasolabial folds. The magnitude and duration of nasolabial fold correction appear to be greater for the HA gel than for the hylan B plus gel.

[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Wolters Kluwer
Loading ...
Support Center