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Tissue Antigens. 2007 Sep;70(3):179-89.

Immunosenescence: deficits in adaptive immunity in the elderly.

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  • 1Experimental Transplantation and Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA. hakimf@mail.nih.gov

Abstract

Aging is associated clinically with increases in the frequency and severity of infectious diseases and an increased incidence of cancer, chronic inflammatory disorders and autoimmunity. These age-associated immune dysfunctions are the consequence of declines in both the generation of new naïve T and B lymphocytes and the functional competence of memory populations. These alterations collectively are termed immunosenescence.

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