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Future Microbiol. 2007 Jun;2(3):297-307.

Extended-spectrum cephalosporinases: structure, detection and epidemiology.

Author information

1
Service de Bactériologie-Virologie, Hôpital de Bicêtre, Le Kremlin-Bicêtre, France. nordmann.patrice@bct.aphp.fr

Abstract

Extended-spectrum AmpC beta-lactamases of Enterobacteriaceae, which are chromosomally or plasmid-encoded, possess structural modifications in the vicinity of the active site compared with their progenitors. They display an increased catalytic efficiency against extended-spectrum beta-lactams, such as ceftazidime, cefotaxime, cefepime, cefpirome and, in some cases, also against imipenem. An overview of the molecular and biochemical characterization of this recently identified mechanism of resistance to beta-lactams is provided as well as its prevalence and possible clinical significance.

PMID:
17661704
DOI:
10.2217/17460913.2.3.297
[Indexed for MEDLINE]

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