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Int J Biochem Cell Biol. 2007;39(12):2183-94. Epub 2007 Jun 24.

TGFBIp/betaig-h3 protein: a versatile matrix molecule induced by TGF-beta.

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  • 1Cell and Matrix Research Institute, Department of Biochemistry and Cell Biology, School of Medicine, Kyungpook National University, 101 Dongin-Dong, Jung-gu, Daegu 700-422, Republic of Korea.

Abstract

TGFBIp/betaig-h3 protein is an extracellular matrix molecule initially cloned from human adenocarcinoma cells treated with TGF-beta. Its precise function remains obscure but a number of studies have demonstrated it to be an intriguingly versatile molecule role in a wide range of physiological and pathological conditions. To date, the most extensively studied and reported action of TGFBIp/betaig-h3 protein is in corneal dystrophy and several excellent reviews are available on this. Work from various laboratories on this molecule has compiled a tremendous amount of information over the past decade and a half. Here we review the current understanding on TGFBIp/betaig-h3 protein and its functions in morphogenesis, extracellular matrix interactions, adhesion/migration, corneal dystrophy, tumorigenesis, angiogenesis, nephropathies, osteogenesis, wound healing and inflammation.

PMID:
17659994
DOI:
10.1016/j.biocel.2007.06.004
[PubMed - indexed for MEDLINE]
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