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World J Gastroenterol. 2007 Jun 28;13(24):3354-8.

Frequent loss of heterozygosity at 8p22 chromosomal region in diffuse type of gastric cancer.

Author information

1
Biochemistry Department, Ahwaz Jondishapoor University of Medical Science, Ahwaz, Iran. hosseini.h@aujums.ac.ir

Abstract

AIM:

To study the loss of heterozygosity (LOH) at 8p21-23 locus in diffuse gastric cancer.

METHODS:

To evaluate the involvement of this region in gastric cancer, we used eight microsatellite markers covering two Mb of mentioned region, to perform a high-resolution analysis of allele loss in 42 cases of late diffuse gastric adenocarcinoma.

RESULTS:

Six of these STS makers: D8S1149, D8S1645, D8S1643, D8S1508, D8S1591, and D8S1145 showed 36%, 28%, 37%, 41%, 44% and 53% LOH, respectively.

CONCLUSION:

A critical region of loss, close to the NAT2 locus and relatively far from FEZ1 gene currently postulated as tumor suppressor gene in this region.

PMID:
17659675
PMCID:
PMC4172716
DOI:
10.3748/wjg.v13.i24.3354
[Indexed for MEDLINE]
Free PMC Article

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