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Breast Cancer Res. 2007;9(4):304.

Estrogen regulation of mammary gland development and breast cancer: amphiregulin takes center stage.

Author information

1
Department of Molecular and Cellular Biology, Baylor College of Medicine, Baylor Plaza, Houston, TX 77030, USA. lamarca@bcm.edu

Abstract

Estrogen-mediated proliferation is fundamental to normal mammary gland development. Recent studies have demonstrated that amphiregulin is a critical paracrine regulator of estrogen action during ductal morphogenesis. These studies implicate a critical role for amphiregulin in mammary stem cell differentiation as well as breast cancer initiation and progression.

PMID:
17659070
PMCID:
PMC2206713
DOI:
10.1186/bcr1740
[Indexed for MEDLINE]
Free PMC Article

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