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Cardiovasc Res. 2008 Jan;77(1):19-29.

Cardiovascular roles of nitric oxide: a review of insights from nitric oxide synthase gene disrupted mice.

Author information

1
Cardiovascular Research Center, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, United States.

Abstract

Nitric oxide (NO) is a gaseous molecule that plays many key roles in the cardiovascular system. Each of the enzymes that generate NO--neuronal, inducible and endothelial NO synthase-has been genetically disrupted in mice. This review discusses the cardiovascular phenotypes of each of the NO synthase (NOS) gene knockout mice, and the insights gained into the roles of NO in the cardiovascular system. Mice lacking the endothelial isoform are hypertensive, have endothelial dysfunction and show a more severe outcome in response to vascular injury, to stroke and cerebral ischaemia, and to diet-induced atherosclerosis. Mice lacking the neuronal isoform show a less severe outcome in response to stroke and cerebral ischaemia but have increased diet-induced atherosclerosis. Mice lacking the inducible isoform show reduced hypotension to septic shock. Together, NOS gene knockout mice have been useful tools that complement our other approaches to studying the multiple roles of NO in the cardiovascular system.

PMID:
17658499
PMCID:
PMC2731989
DOI:
10.1016/j.cardiores.2007.06.024
[Indexed for MEDLINE]
Free PMC Article

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