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Clin Lab Med. 2007 Sep;27(3):653-70, viii.

Cellular image analysis and imaging by flow cytometry.

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1
Amnis Corporation, Seattle, 2505 Third Avenue, Suite 210, WA 98121, USA. dbasiji@amnis.com

Abstract

Imaging flow cytometry combines the statistical power and fluorescence sensitivity of standard flow cytometry with the spatial resolution and quantitative morphology of digital microscopy. The technique is a good fit for clinical applications by providing a convenient means for imaging and analyzing cells directly in bodily fluids. Examples are provided of the discrimination of cancerous from normal mammary epithelial cells and the high-throughput quantitation of fluorescence in situ hybridization (FISH) probes in human peripheral blood mononuclear cells. The FISH application will be enhanced further by the integration of extended depth-of-field imaging technology with the current optical system.

PMID:
17658411
PMCID:
PMC2034394
DOI:
10.1016/j.cll.2007.05.008
[Indexed for MEDLINE]
Free PMC Article
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