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Cell Signal. 2007 Oct;19(10):2003-12. Epub 2007 Jun 12.

Vascular endothelial growth factor receptor-2: structure, function, intracellular signalling and therapeutic inhibition.

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North West Cancer Research Fund Institute, School of Biological Sciences, College of Natural Sciences, University of Wales, Bangor, UK.


Vascular endothelial growth factors (VEGFs) regulate vascular development, angiogenesis and lymphangiogenesis by binding to a number of receptors. VEGFR-1 is required for the recruitment of haematopoietic stem cells and the migration of monocytes and macrophages, VEGFR-2 regulates vascular endothelial function and VEGFR-3 regulates lymphatic endothelial cell function. Over the last decade, considerable progress has been made in delineating the VEGFR-2 specific intracellular signalling cascades leading to proliferation, migration, survival and increased permeability, each of which contributes to the angiogenic response. Furthermore, therapeutic inhibition of VEGFR-2 action is now having an impact in the clinic for the treatment of a number of diseases.

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