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Am J Respir Cell Mol Biol. 2008 Jan;38(1):57-67. Epub 2007 Jul 26.

Pulmonary exposure to particles during pregnancy causes increased neonatal asthma susceptibility.

Author information

1
Harvard School of Public Health, Dept. of Environmental Health, Molecular and Integrative Physiological Sciences Program, 665 Huntington Ave, HSPH-12, Room 1313, Boston, MA 02115, USA. afedulov@hsph.harvard.edu

Abstract

Maternal immune responses can promote allergy development in offspring, as shown in a model of increased susceptibility to asthma in babies of ovalbumin (OVA)-sensitized and -challenged mother mice. We investigated whether inflammatory responses to air pollution particles (diesel exhaust particles, DEP) or control "inert" titanium dioxide (TiO(2)) particles are enhanced during pregnancy and whether exposure to particles can cause increased neonatal susceptibility to asthma. Pregnant BALB/c mice (or nonpregnant controls) received particle suspensions intranasally at Day 14 of pregnancy. Lung inflammatory responses were evaluated 48 hours after exposure. Offspring of particle- or buffer-treated mothers were sensitized and aerosolized with OVA, followed by assays of airway hyperresponsiveness (AHR) and allergic inflammation (AI). Nonpregnant females had the expected minimal response to "inert" TiO(2). In contrast, pregnant mice showed robust and persistent acute inflammation after both TiO(2) and DEP. Genomic profiling identified genes differentially expressed in pregnant lungs exposed to TiO(2). Neonates of mothers exposed to TiO(2) (and DEP, but not PBS) developed AHR and AI, indicating that pregnancy exposure to both "inert" TiO(2) and DEP caused increased asthma susceptibility in offspring. We conclude that (1) pregnancy enhances lung inflammatory responses to otherwise relatively innocuous inert particles; and (2) exposures of nonallergic pregnant females to inert or toxic environmental air particles can cause increased allergic susceptibility in offspring.

PMID:
17656681
PMCID:
PMC2176127
DOI:
10.1165/rcmb.2007-0124OC
[Indexed for MEDLINE]
Free PMC Article

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