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J Am Soc Nephrol. 2007 Oct;18(10):2623-7. Epub 2007 Jul 26.

Glycemic control and critical illness: is the kidney involved?

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  • 1UCSD Medical Center 8342, 200 W. Arbor Drive, San Diego, CA 92103, USA.


The pathophysiology, consequences, and management of hyperglycemia during critical illness is an important clinical issue. Uncontrolled hyperglycemia in this setting is associated with a variety of adverse events, including mortality. The kidneys have a major role in glucose and insulin metabolism, and emerging evidence suggests that they both are actively involved in the development, maintenance, and resolution of hyperglycemia. The development of acute kidney injury is also a risk in this setting. This article discusses potential approaches for efficient and effective management of hyperglycemia.

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