A new cytotoxic carbazole alkaloid from Clausena excavata

Y H Taufiq-Yap; T H Peh; G C L Ee; M Rahmani; M A Sukari; A M Ali; R Muse

doi:10.1080/14786410701258875

A new cytotoxic carbazole alkaloid from Clausena excavata

Nat Prod Res. 2007 Jul 20;21(9):810-3. doi: 10.1080/14786410701258875.

Authors

Y H Taufiq-Yap¹, T H Peh, G C L Ee, M Rahmani, M A Sukari, A M Ali, R Muse

Affiliation

¹ Department of Chemistry, Universiti Putra Malaysia, Selangor, Malaysia. yap@fsas.upm.edu.my

PMID: 17654285
DOI: 10.1080/14786410701258875

Abstract

A new carbazole alkaloid, 3-carbomethoxy-2-hydroxy-7-methoxycarbazole, Clausine-TY (1), together with two known carbazole alkaloid, Clausine-H (2) and Clausine-B (3), were isolated from the ethyl acetate extract of the stem bark of the Malaysian Clausena excavata. The structures of these compounds were elucidated by spectroscopic analyses. The new carbazole alkaloid shows significant cytotoxicity against CEM-SS cell line.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Carbazoles / chemistry
Carbazoles / isolation & purification*
Carbazoles / therapeutic use
Cell Line, Tumor
Heterocyclic Compounds, 3-Ring / isolation & purification
Heterocyclic Compounds, 3-Ring / therapeutic use
Humans
Leukemia, Lymphoid / drug therapy
Magnetic Resonance Spectroscopy
Molecular Structure
Plant Bark / chemistry*
Rutaceae / chemistry*

Substances

Carbazoles
Heterocyclic Compounds, 3-Ring
clausine H
clausine-B
clausine-TY