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Nature. 2007 Jul 26;448(7152):435-8.

A lipid-based model for the creation of an escape hatch from the endoplasmic reticulum.

Author information

1
Whitehead Institute, MIT Department of Biology, Cambridge, Massachusetts 02142, USA. ploegh@wi.mit.edu

Abstract

Lipids are not encoded by a DNA template and therefore cannot be mutated, knocked out or knocked down. This by no means renders them impotent from a cell biological perspective. Here I propose a model for the involvement of lipid rearrangements in the execution of crucial steps in (glyco)protein quality control.

PMID:
17653186
DOI:
10.1038/nature06004
[Indexed for MEDLINE]

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