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Epilepsia. 2007 Dec;48(12):2357-60. Epub 2007 Jul 25.

A controlled prospective investigation of psychiatric comorbidity in temporal lobe epilepsy.

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Department of Neurology and Biostatistics, University of Wisconsin, Madison, Wisconsin 53792, USA.


Temporal lobe epilepsy patients (n = 48) and healthy controls (n = 69) underwent structured psychiatric interview at baseline and 4 years later to characterize the course of DSM-IV Axis I disorders. Adjusting for the influence of prior psychiatric history, epilepsy subjects exhibit significantly greater risk of interval episodes of Total Axis I Disorders and Mood Disorders, indicating a poorer prognosis for these comorbidities in the context of chronic temporal lobe epilepsy.

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