[Comparative study of behavioral effects of cortexin and cerebrolysine upon intraventricular and intraperitoneal administration in rats]

Eksp Klin Farmakol. 2007 May-Jun;70(3):13-9.
[Article in Russian]

Abstract

The comparative central effects of polypeptide drugs cortexin and cerebrolysin were studied in Wistar rats after introduction into the cerebral ventriculi in a dose range from 1 mg to 10 mg and 100 mg and after intraperitoneal injections in a dose of 1 mg/kg. Both drugs produced a moderate psychostimulant action, cortexin being more effective as compared to cerebrolysin. This effect was confirmed by all methods studied, including open field, elevated plus-maze, intruder-resident, and self-stimulation of the lateral hypothalamus. It is suggested that cortexin and cerebrolysin have similar mode of action, while cortexin is more effective than cerebrolysin. A difference between the intraventricular and intraperitoneal effects of drugs was that in the first case both drugs produced a moderate anxiolytic action, while in the second case an anxiogenic effect was registered. The central anxiolytic effect of drugs is probably related to a nonspecific action of polypeptides administered via brain ventriculi.

Publication types

  • Comparative Study

MeSH terms

  • Amino Acids / administration & dosage
  • Amino Acids / pharmacology*
  • Animals
  • Anti-Anxiety Agents / administration & dosage
  • Anti-Anxiety Agents / pharmacology*
  • Behavior, Animal / drug effects*
  • Central Nervous System Stimulants / administration & dosage
  • Central Nervous System Stimulants / pharmacology*
  • Injections, Intraperitoneal
  • Injections, Intraventricular
  • Intercellular Signaling Peptides and Proteins
  • Male
  • Neuroprotective Agents / administration & dosage
  • Neuroprotective Agents / pharmacology*
  • Peptides / administration & dosage
  • Peptides / pharmacology*
  • Rats
  • Rats, Wistar

Substances

  • Amino Acids
  • Anti-Anxiety Agents
  • Central Nervous System Stimulants
  • Intercellular Signaling Peptides and Proteins
  • Neuroprotective Agents
  • Peptides
  • cerebrolysin
  • cortexin