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Nat Rev Cancer. 2007 Aug;7(8):599-612.

Molecular mechanisms of alcohol-mediated carcinogenesis.

Author information

1
Department of Medicine and Laboratory of Alcohol Research, Liver Disease and Nutrition, Salem Medical Centre, University of Heidelberg, Heidelberg, Germany. helmut_karl.seitz@urz.uni-heidelberg.de

Abstract

Approximately 3.6% of cancers worldwide derive from chronic alcohol drinking, including those of the upper aerodigestive tract, the liver, the colorectum and the breast. Although the mechanisms for alcohol-associated carcinogenesis are not completely understood, most recent research has focused on acetaldehyde, the first and most toxic ethanol metabolite, as a cancer-causing agent. Ethanol may also stimulate carcinogenesis by inhibiting DNA methylation and by interacting with retinoid metabolism. Alcohol-related carcinogenesis may interact with other factors such as smoking, diet and comorbidities, and depends on genetic susceptibility.

PMID:
17646865
DOI:
10.1038/nrc2191
[Indexed for MEDLINE]

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