Format

Send to

Choose Destination
See comment in PubMed Commons below
Am J Clin Dermatol. 2007;8(4):189-94.

Cancer concerns with topical immunomodulators in atopic dermatitis: overview of data and recommendations to clinicians.

Author information

1
Division of Dermatology, Department of Medicine, University of Tennessee, Memphis, Tennessee 38104, USA.

Abstract

The topical immunomodulators tacrolimus and pimecrolimus were approved for the treatment of atopic dermatitis in 2000 and 2001, respectively. However, on 20 January 2006, the US FDA approved a 'black box' warning for these agents because of concerns regarding a possible link to development of malignancy. These concerns were based upon the known mechanism of action of this drug class, the results of animal studies, and case reports. This article provides an overview of the data that led to the approval by the FDA of a 'black box' warning and concludes that physicians, patients, and caregivers should feel confident about using tacrolimus and pimecrolimus for atopic dermatitis so long as they follow the FDA guidelines.

PMID:
17645374
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments

    Supplemental Content

    Loading ...
    Support Center