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Biochimie. 1991 Jun;73(6):631-8.

Structure and organization of ribosomal DNA.

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  • 1Department of Molecular Microbiology, Washington University School of Medicine, St Louis, MO 63110.


Three trends are seen in the organization of ribosomal DNA genes during evolution: 1) gradual separation and separability of the regulation of transcription of 5S and larger subunit rRNAs; 2) retention of a transcription unit containing both large and small rRNAs; and 3) clustering of genes for both 5S and 18S-28S rDNAs, with the possible association of other 'non-rDNA' in the clusters of 18S-28S rDNA genes by the time mammals evolve.

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