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Int J Antimicrob Agents. 2007 Sep;30(3):242-9. Epub 2007 Jul 17.

Potential management of resistant microbial infections with a novel non-antibiotic: the anti-inflammatory drug diclofenac sodium.

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1
Institute of Laboratory Animal Resources, Laboratory Animal Medicine, College of Veterinary Medicine, 85-Dong, 733-Ho, Seoul National University, San 56-1, Sillim 9 Dong, Gwanakgu, Seoul, South Korea.

Abstract

Diclofenac sodium (Dc), an anti-inflammatory agent, has remarkable inhibitory action both against drug-sensitive and drug-resistant clinical isolates of various Gram-positive and Gram-negative bacteria. The aim of this study was to determine the ability of Dc to protect mice from a virulent Salmonella infection. Dc injected at 1.5 microg/g and 3.0 microg/g mouse body weight significantly protected animals from the lethality of Salmonella infection. As was the case for the in vitro interaction, Dc in combination with streptomycin was even more effective. The non-antibiotic drug Dc has potential for the management of problematic antibiotic-resistant bacterial infections.

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