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Curr Opin Plant Biol. 2007 Aug;10(4):366-71. Epub 2007 Jul 23.

Networks of WRKY transcription factors in defense signaling.

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Center for Plant Cell Biology, Department of Botany and Plant Sciences, University of California at Riverside, CA 92521, USA.


Members of the complex family of WRKY transcription factors have been implicated in the regulation of transcriptional reprogramming associated with plant immune responses. Recently genetic evidence directly proving their significance as positive and negative regulators of disease resistance has accumulated. WRKY genes were shown to be functionally connected forming a transcriptional network composed of positive and negative feedback loops and feed-forward modules. Within a web of partially redundant elements some WRKY factors hold central positions mediating fast and efficient activation of defense programs. A key mechanism triggering strong immune responses appears to be based on the inactivation of defense-suppressing WRKY proteins.

[Indexed for MEDLINE]

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