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Autoimmun Rev. 2007 Aug;6(7):476-81. Epub 2007 Mar 7.

Susceptibility of naïve and subsets of memory T cells to apoptosis via multiple signaling pathways.

Author information

1
Division of Basic and Clinical Immunology, Medical Sciences I, C-240, University of California, Irvine, CA 92697, USA. sgupta@uci.edu

Abstract

Apoptosis is mediated via death receptor, the mitochondrial, and the endoplasmic reticulum pathway. Following activation of naïve T cells with antigens, different subsets of memory T cells are generated. In this review we have discussed relative sensitivity/resistance of naïve and different subsets of memory T cells to apoptosis via different signaling pathways. Molecular basis for differential sensitivity to apoptosis is discussed.

PMID:
17643936
DOI:
10.1016/j.autrev.2007.02.005
[Indexed for MEDLINE]

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