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Bioorg Med Chem Lett. 2007 Sep 15;17(18):5251-5. Epub 2007 Jun 30.

PASS-predicted design, synthesis and biological evaluation of cyclic nitrones as nootropics.

Author information

1
Department of Applied Chemistry, Guru Nanak Dev University, Amritsar 143005, Punjab, India.

Abstract

Out of 400 virtually designed imidazoline N-oxides, five cyclic nitrones were selected on the basis of PASS prediction as potent nootropics and were evaluated for their biological activities in albino mice. The selected N-alkyl and aryl-substituted nitrones were found to be excellent nootropics. A series of lead compounds acting as cognition enhancers have been provided, which can be further exploited in search of such New Chemical Entities (NCEs).

PMID:
17643300
DOI:
10.1016/j.bmcl.2007.06.071
[Indexed for MEDLINE]

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