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J Pediatr Endocrinol Metab. 2007 May;20(5):621-32.

Carbohydrate metabolism changes in cystic fibrosis.

Author information

1
Paediatric Endocrinology Unit, Paediatrics Service, Hospital Universitario Materno Infantil de Canarias, Las Palmas, Spain. argdom@wanadoo.es

Abstract

AIMS:

To assess the prevalence of impaired glucose tolerance (ITG) and diabetes mellitus (DMRCF) in a group of patients with cystic fibrosis (CF). To study clinical status-related variables and to compare age with the evolution of their carbohydrate metabolism (CHM).

PATIENTS AND METHODS:

Thirty patients with CF (1.5-26 years). Oral glucose tolerance test (OGTT) in 28 patients.

RESULTS:

Three patients (10%) showed ITG and four DMRCF (13.3%). CF patients with impaired CHM (ICHM) were older (p = 0.006), and had longer times since diagnosis and first sputum colonization (p = 0.001, p < 0.001). Homozygous deltaF508 mutation was significant (p = 0.001). Insulin peak, area under the curve for insulin, insulin resistance, insulin sensitivity, and pancreatic beta-cell function were all significant.

CONCLUSIONS:

ICHM was present in 23.3%. Age, time since diagnosis of CF, first sputum colonization and homozygous deltaF508 mutation were significantly associated. CHM in patients with CF is similar to that in the population without CF in the early years.

PMID:
17642423
DOI:
10.1515/jpem.2007.20.5.621
[Indexed for MEDLINE]

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