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Proc Natl Acad Sci U S A. 2007 Jul 24;104(30):12554-9. Epub 2007 Jul 19.

Modafinil enhances thalamocortical activity by increasing neuronal electrotonic coupling.

Author information

1
Department of Physiology and Neuroscience, New York University Medical Center, 550 First Avenue, New York, NY 10016, USA.

Abstract

Modafinil (Provigil, Modiodal), an antinarcoleptic and mood-enhancing drug, is shown here to sharpen thalamocortical activity and to increase electrical coupling between cortical interneurons and between nerve cells in the inferior olivary nucleus. After irreversible pharmacological block of connexin permeability (i.e., by using either 18beta-glycyrrhetinic derivatives or mefloquine), modafinil restored electrotonic coupling within 30 min. It was further established that this restoration is implemented through a Ca(2+)/calmodulin protein kinase II-dependent step.

PMID:
17640897
PMCID:
PMC1925036
DOI:
10.1073/pnas.0705087104
[Indexed for MEDLINE]
Free PMC Article

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