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Biol Psychiatry. 2008 Feb 15;63(4):385-90. Epub 2007 Jul 20.

Amygdala and hippocampal volumes in familial early onset major depressive disorder.

Author information

1
Department of Psychiatry and Behavioral Neurosciences, Wayne State University, Children's Hospital of Michigan, Detroit, Michigan 48201, USA.

Abstract

BACKGROUND:

Abnormalities in the amygdala and hippocampus have been implicated in the pathogenesis of major depressive disorder (MDD). To our knowledge, no prior study has examined amygdala-hippocampus anatomy in pediatric patients with familial MDD (at least one first degree relative with MDD).

METHODS:

Thirty-two psychotropic-naive patients with familial MDD, aged 8-21 years (12 males and 20 females), and 35 group-matched healthy participants (13 males and 22 females) underwent volumetric magnetic resonance imaging in order to evaluate hippocampal and amygdala volumes.

RESULTS:

Patients with familial MDD had significantly smaller left hippocampal (p = .007, effect size [d] = .44) and right hippocampal volumes (p = .025, d = .33) than controls. No differences were noted in amygdala volumes between groups (right: p > .05, left: p > .05). No correlations between hippocampal or amygdala volumes and demographic or clinical variables were noted.

CONCLUSIONS:

Reduced hippocampal volume may be suggestive of a risk factor for developing MDD.

PMID:
17640621
PMCID:
PMC2268763
DOI:
10.1016/j.biopsych.2007.05.005
[Indexed for MEDLINE]
Free PMC Article
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