Abstract
1. L-Ornithine transport by plasma-membrane vesicles isolated from Ehrlich cells is Na(+)-independent and shows a saturable and a diffusional component. 2. Putrescine, histamine, 5-hydroxytryptamine and 2,3-diaminopropane at 55 microM concentration significantly inhibit 0.5 mM-L-ornithine transport at least for the first 10 min of incubation. 3. There is a trans-stimulatory effect of putrescine on L-ornithine transport.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Biological Transport / drug effects
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Carcinoma, Ehrlich Tumor / metabolism*
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Cell Membrane / metabolism*
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Diamines / pharmacology*
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Glutamine / metabolism
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Histamine / pharmacology
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Humans
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Ornithine / metabolism*
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Putrescine / pharmacology
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Serotonin / pharmacology
Substances
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Diamines
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Glutamine
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Serotonin
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1,2-diaminopropane
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Histamine
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Ornithine
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Putrescine