Diamines interfere with the transport of L-ornithine in Ehrlich-cell plasma-membrane vesicles

Biochem J. 1991 Dec 15;280 ( Pt 3)(Pt 3):825-7. doi: 10.1042/bj2800825.

Abstract

1. L-Ornithine transport by plasma-membrane vesicles isolated from Ehrlich cells is Na(+)-independent and shows a saturable and a diffusional component. 2. Putrescine, histamine, 5-hydroxytryptamine and 2,3-diaminopropane at 55 microM concentration significantly inhibit 0.5 mM-L-ornithine transport at least for the first 10 min of incubation. 3. There is a trans-stimulatory effect of putrescine on L-ornithine transport.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Biological Transport / drug effects
  • Carcinoma, Ehrlich Tumor / metabolism*
  • Cell Membrane / metabolism*
  • Diamines / pharmacology*
  • Glutamine / metabolism
  • Histamine / pharmacology
  • Humans
  • Ornithine / metabolism*
  • Putrescine / pharmacology
  • Serotonin / pharmacology

Substances

  • Diamines
  • Glutamine
  • Serotonin
  • 1,2-diaminopropane
  • Histamine
  • Ornithine
  • Putrescine