Format

Send to

Choose Destination
J Clin Psychiatry. 2007;68 Suppl 8:17-25.

Prevalence and management of treatment-resistant depression.

Author information

1
Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA, USA. cnemero@emory.edu

Abstract

Treatment-resistant depression (TRD) is a major public health problem in terms of its prevalence and in terms of individual suffering and cost to society. Best estimates indicate 12-month prevalence rates of approximately 3% for Stage 1 TRD (failure to respond to 1 adequate trial of an antidepressant) and approximately 2% for Stage 2 TRD (failure to respond to 2 adequate trials). The current article provides a brief review of the definitions, prevalence, and various treatment options for TRD, including switching, augmentation, and combination therapies and use of nonpharmacologic treatments. Given the public health importance of TRD, the relative absence of adequately powered, double-blind trials is striking.

PMID:
17640154
[Indexed for MEDLINE]
Free full text

Supplemental Content

Full text links

Icon for Physicians Postgraduate Press, Inc.
Loading ...
Support Center