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Nano Lett. 2007 Aug;7(8):2513-20. Epub 2007 Jul 19.

Real-time imaging of astrocyte response to quantum dots: in vivo screening model system for biocompatibility of nanoparticles.

Author information

1
Department of Pharmacology and Therapeutics, McGill University, Montreal, Quebec, Canada. dusica.maysinger@mcgill.ca

Abstract

Astrocytes are the principle macroglial brain cells. They are activated by different stressors and brain injuries. Quantum dots (QDs) can cause oxidative stress. This study shows a real-time imaging of primary cortical cultures and assessment of QD-induced activation of astrocytes in the brains of transgenic mice with the luciferase gene driven by the murine astrocyte promoter. This approach may be widely applicable for assessing the astroglia/tissue response to nanoparticles in live animals.

PMID:
17638392
DOI:
10.1021/nl071611t
[Indexed for MEDLINE]

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