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Immunol Cell Biol. 2007 Aug-Sep;85(6):420-4. Epub 2007 Jul 17.

Coordinating TLR-activated signaling pathways in cells of the immune system.

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Immunology Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.


Toll-like receptor (TLR) signaling leads to the activation of mitogen-activated protein kinase and nuclear factor-kappaB signaling pathways. While the upstream signaling events initiated at the level of adaptors and the activation of the downstream signaling pathways have received a lot of attention, our understanding of how these signaling pathways are coordinated to regulate gene expression is poorly understood. This review gives a selective overview on our current understanding of signaling downstream of TLRs, with an emphasis on how the upstream kinases like the mitogen-activated protein kinase kinase kinases (TAK1 and Tpl2) and inhibitor of kappa-B kinase (IKK) coordinate the signaling events that steer the course of an immune response.

[Indexed for MEDLINE]

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