Format

Send to

Choose Destination
See comment in PubMed Commons below
Curr Biol. 2007 Jul 17;17(14):R549-51.

Calcium signaling: pyruvate and CRAC meet at the crossroads.

Author information

1
Department of Physiology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA. Shmuel.muallem@utsouthwestern.edu

Abstract

Receptor-evoked Ca(2+) influx is mediated by store-operated Ca(2+) channels, such as the CRAC channel, which mediates the I(crac) current. Recent work reveals that pyruvate, the precursor substrate for the Krebs cycle, regulates I(crac) to prolong Ca(2+) influx into the cell, thereby coupling oxidation of glucose and its own metabolism in the mitochondria to Ca(2+) influx by the CRAC channel.

PMID:
17637355
DOI:
10.1016/j.cub.2007.05.037
[Indexed for MEDLINE]
Free full text
PubMed Commons home

PubMed Commons

0 comments

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Support Center