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Zhong Yao Cai. 2007 Mar;30(3):377-80.

[Effect of Fuzheng Peiben therapy on dendritic cell in patients with breast cancer].

[Article in Chinese]

Author information

1
Department of General Surgery, Zhujiang Hospital, Southern Medical University, Guangzhou 510282, China.

Abstract

OBJECTIVE:

To investigate the repairing mechanism of Fuzheng Peiben Therapy on cellular immunofunction in patients with breast cancer on cellar and molecular level.

METHODS:

The tumor tissue and axillary lymph node samples were evaluated with the flow cytometry for CD83, CD80, CD86 before and after neoadujvant therapy.

RESULTS:

The levels of CD83, CD80, CD86 were singificantly decreased in group A (treated with surgery only), B (treated with neoadujvant chemotherapy plus surgery) and C (treated with neoadujvant chemotherapy plus surgery with shenqi Fuzheng Injection) compared with that in normal team (P < 0.05 or 0.01); The levels of CD83, CD80, CD86 were significantly decreased in group A, B and C compared between before and after neoadujvant chemotherapy (P < 0.05 or 0.01); They were not significantly decreased between group A and group C (P > 0.05).

CONCLUSION:

The cellular immunity was inpaired considerably by neoadujvant chemotherapy. Neoadjuvant chemotherapy combined with Shenqi Fuzheng Injection can enhance the cellular immunity considerably.

PMID:
17634051
[Indexed for MEDLINE]

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