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Clin Exp Rheumatol. 2007 May-Jun;25(3):457-60.

Propionibacterium acnes and SAPHO syndrome: a case report and literature review.

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Sezione di Reumatologia, Dipartimento di Medicina Clinica e Sperimentale, Università degli Studi di Ferrara, and Dipartimento di Patologia ed Oncologia, Azienda Ospedaliera/Universitaria Arcispedale Sant'Anna, Ferrara, Italy.



To describe the presence of Propionibacterium acnes (P. acnes) in a series of patients with SAPHO syndrome in which a bone biopsy has been carried out and to discuss the results comparing them to the data described in the literature.


In 6 out of 56 patients with SAPHO syndrome, a bone biopsy from osteitic lesion was carried out. This invasive investigation was performed only in those cases in which it was necessary to clarify the diagnosis.


Of the 6 biopsies processed, P. acnes was isolated in only one case. No other infectious agents were identified.


P. acnes is not often found in bone lesions of SAPHO syndrome. A bone biopsy may represent a procedure useful for corroborating the diagnosis or for excluding other diseases only in specific cases.

[Indexed for MEDLINE]

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