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Comput Biol Chem. 2007 Aug;31(4):239-45. Epub 2007 Apr 6.

Inferring gene regulatory networks from temporal expression profiles under time-delay and noise.

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1
Bio-MAX Institute, Seoul National University, Gwanak-gu, Seoul 151-818, Republic of Korea.

Abstract

Ordinary differential equations (ODE) have been widely used for modeling and analysis of dynamic gene networks in systems biology. In this paper, we propose an optimization method that can infer a gene regulatory network from time-series gene expression data. Specifically, the following four cases are considered: (1) reconstruction of a gene network from synthetic gene expression data with noise, (2) reconstruction of a gene network from synthetic gene expression data with time-delay, (3) reconstruction of a gene network from synthetic gene expression data with noise and time-delay, and (4) reconstruction of a gene network from experimental time-series data in budding yeast cell cycle.

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