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Drug Discov Today. 2007 Jul;12(13-14):561-8. Epub 2007 Jun 26.

Local delivery of proteins and the use of self-assembling peptides.

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Cardiovascular Division, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, 65 Landsdowne Street, Cambridge, MA 02139, USA.


Self-assembling peptides are members of a new class of molecules designed for tissue engineering and protein delivery. Upon injection in a physiological environment, self-assembling peptides form stable nanofiber hydrogels. Such biocompatible nanofibers can support three-dimensional growth and differentiation of many cell types. Self-assembling peptides are promising candidates for protein delivery, because they allow non-covalent binding of proteins, tethering of proteins, or incorporation of fusion proteins. Self-assembling peptides can be designed to deliver individual proteins or multiple factors, because the building blocks comprising self-assembling peptides can be designed with great flexibility.

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