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Proc Natl Acad Sci U S A. 1991 Dec 15;88(24):11460-4.

Sterically stabilized liposomes: improvements in pharmacokinetics and antitumor therapeutic efficacy.

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1
Department of Pharmacology, University of California, San Francisco 94143.

Abstract

The results obtained in this study establish that liposome formulations incorporating a synthetic polyethylene glycol-derivatized phospholipid have a pronounced effect on liposome tissue distribution and can produce a large increase in the pharmacological efficacy of encapsulated antitumor drugs. This effect is substantially greater than that observed previously with conventional liposomes and is associated with a more than 5-fold prolongation of liposome circulation time in blood, a marked decrease in uptake by tissues such as liver and spleen, and a corresponding increased accumulation in implanted tumors. These and other properties described here have expanded considerably the prospects of liposomes as an effective carrier system for a variety of pharmacologically active macromolecules.

PMID:
1763060
PMCID:
PMC53155
[Indexed for MEDLINE]
Free PMC Article
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