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AIDS. 2007 Jul 31;21(12):1625-9.

How many sexually-acquired HIV infections in the USA are due to acute-phase HIV transmission?

Author information

1
Center for AIDS Intervention Research, Department of Psychiatry and Behavioral Medicine, Medical College of Wisconsin, 2071 North Summit Avenue, Milwaukee, WI 53202, USA. pinkrton@mcw.edu

Abstract

OBJECTIVE:

To estimate the number of persons in the USA who acquire HIV as a consequence of risky sexual activities with an acutely-infected sex partner.

METHODS:

Estimates of the number of incident infections in the USA that are due to acute-phase HIV transmission were derived from a simple mathematical model that combined epidemiological data with information regarding the relative transmission rates for acutely-infected, nonacutely infected but serostatus-unaware, and serostatus-aware persons living with HIV.

RESULTS:

Approximately 2760 (8.6%) of the estimated 32 000 sexually-acquired HIV infections in the USA each year are due to acute-phase transmission of the virus. Multivariate sensitivity analyses with a liberal range of values for key parameters produced an upper bound of 5537 infections, representing 17.3% of the total number of sexually-acquired infections.

CONCLUSIONS:

Acute-phase HIV transmission accounts for fewer sexually-acquired infections in the USA than is generally assumed.

PMID:
17630558
PMCID:
PMC2377417
DOI:
10.1097/QAD.0b013e32826fb6a6
[Indexed for MEDLINE]
Free PMC Article

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