Format

Send to

Choose Destination
See comment in PubMed Commons below
Cell Cycle. 2007 Jul 15;6(14):1718-23. Epub 2007 May 25.

The role of ubiquitination in the direct mitochondrial death program of p53.

Author information

1
Department of Pathology, Stony Brook University, Stony Brook, New York 11794, USA.

Abstract

p53 ubiquitination at C-terminal lysines by MDM2 and other E3 ligases had been considered a straightforward negative regulation of p53 with only one function, that is marking the protein for proteasomal degradation. In this review, we will focus on the recently uncovered activating role of ubiquitination in the transcription-independent direct mitochondrial death program of p53.

PMID:
17630506
DOI:
10.4161/cc.6.14.4503
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Taylor & Francis
    Loading ...
    Support Center