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Cerebrovasc Dis. 2007;24(2-3):236-41. Epub 2007 Jun 28.

Small-vessel vascular disease in human immunodeficiency virus infection: the Hawaii aging with HIV cohort study.

Author information

1
Department of Medicine, John A. Burns School of Medicine, University of Hawaii, Honolulu, Hawaii 96816, USA. aaronmnm@hawaii.edu

Abstract

BACKGROUND:

This study is designed to determine the relationship between age and occurrence of cerebral manifestations of small-vessel ischemic vascular disease in human immunodeficiency virus (HIV)-seropositive individuals.

METHODS:

Periventricular leukoaraiosis severity and white matter lesion volume were determined by magnetic resonance imaging of the brain of 57 HIV-seropositive individuals.

RESULTS:

Cerebral small-vessel ischemic vascular disease manifestations correlated with age and systolic blood pressure, but not with HIV infection-related parameters.

CONCLUSIONS:

These findings suggest that, in the era of highly active antiretroviral therapy, leukoaraiosis severity and white matter lesion volume may be more indicative of small-vessel ischemic vascular disease than HIV-related CNS pathology, and support the need for aggressive treatment of vascular risk factors in HIV-seropositive individuals.

PMID:
17630484
DOI:
10.1159/000104484
[Indexed for MEDLINE]
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