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Diabetes Care. 2007 Oct;30(10):2588-92. Epub 2007 Jul 13.

Serum levels of adipokine retinol-binding protein-4 in relation to renal function.

Author information

1
Department of Internal Medicine III, University of Leipzig, Leipzig, Germany.

Abstract

OBJECTIVE:

Retinol-binding protein (RBP)-4 was recently identified as an adipokine that induces insulin resistance. In the current study, we investigated RBP-4 serum levels in diabetic and nondiabetic patients on chronic hemodialysis (CD) compared with control subjects with a glomerular filtration rate >50 ml/min. The majority of the diabetic subjects used oral hypoglycemic agents or insulin.

RESEARCH DESIGN AND METHODS:

RBP-4 was determined by enzyme-linked immunosorbent assay in control subjects (n = 59) and CD patients (n = 58) and correlated with clinical and biochemical measures of renal function, glucose and lipid metabolism, and inflammation in both groups.

RESULTS:

Mean serum RBP-4 levels were almost fourfold higher in CD patients (102 +/- 30 mg/l) compared with control subjects (28 +/- 8 mg/l). Furthermore, serum creatinine independently predicted RBP-4 concentrations in multiple regression analyses in both control subjects and CD patients. In addition, C-reactive protein and systolic blood pressure independently and negatively correlated with RBP-4 serum concentrations in CD patients but not control subjects. In contrast, markers of glucose and lipid metabolism were not independently related to serum RBP-4 in control subjects or CD patients.

CONCLUSIONS:

We show that markers of renal function are independently related to serum RBP-4 levels.

PMID:
17630267
DOI:
10.2337/dc07-0275
[Indexed for MEDLINE]

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