Phosphine-catalyzed synthesis of highly functionalized coumarins

Org Lett. 2007 Aug 2;9(16):3069-72. doi: 10.1021/ol071181d. Epub 2007 Jul 13.

Abstract

2-Styrenyl allenoates are converted into cyclopentene-fused dihydrocoumarins through phosphine-catalyzed regio- and diastereoselective [3 + 2] cycloadditions. Remarkably, changing the solvent from THF to benzene promotes the conversion of the 2-(2-nitrostyrenyl) allenoate into a tricyclic nitronate through a previously undocumented mode of phosphine catalysis. This nitronate was subjected to efficient face-, regio-, and exo-selective 1,3-dipolar cycloadditions to provide tetracyclic coumarin derivatives.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Catalysis
  • Coumarins / chemical synthesis*
  • Molecular Structure
  • Phosphines / chemistry*
  • Stereoisomerism

Substances

  • Coumarins
  • Phosphines
  • phosphine