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J Neuroimmunol. 2007 Aug;188(1-2):181-6. Epub 2007 Jul 12.

The effect of season on cytokine expression in multiple sclerosis and healthy subjects.

Author information

1
School of Medicine, University of Tasmania, Hobart, Tasmania, Australia. nstewart@utas.edu.au <nstewart@utas.edu.au>

Abstract

We measured the levels of IFNgamma, TNFalpha, Il-4 and Il-10 produced by mitogen-stimulated peripheral blood mononuclear cells (PBMC) from healthy people, and those with the relapse/remitting form of multiple sclerosis. Blood was taken in summer and winter. Healthy people had a summer excess of Il-4, Il-10 and TNFalpha, and a winter excess of IFNgamma. Untreated MS cases had a summer excess of Il-10, whereas those treated with Interferon-beta had lower levels of all cytokines, and displayed no seasonal effect.

PMID:
17628701
DOI:
10.1016/j.jneuroim.2007.06.012
[Indexed for MEDLINE]

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