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J Affect Disord. 2008 Feb;106(1-2):91-7. Epub 2007 Jul 12.

Modal subcomponents of metabolic syndrome in patients with bipolar disorder.

Author information

1
Department of Psychiatry, UCLA Mood Disorders Research Program, David Geffen School of Medicine at UCLA, Los Angeles, United States.

Abstract

BACKGROUND:

The metabolic syndrome is a growing global public health problem.

OBJECTIVE:

To evaluate the prevalence rate and modal subcomponents of the metabolic syndrome in subjects treated at the West Los Angeles Veterans Administration Medical Center Bipolar Clinic.

METHODS:

In this cross-sectional design study, using the National Cholesterol Education Program definition, metabolic syndrome prevalence rates were calculated.

RESULTS:

48/98 (49%) of subjects met criteria for metabolic syndrome. There was no difference in prevalence rate by gender or race. Almost 70% of the cohort met criteria for metabolic syndrome by the components of reduced HDL and increased waist circumference. Treatment with carbamazepine at study entry was associated with a lower prevalence rate of metabolic syndrome.

LIMITATIONS AND CONCLUSIONS:

This study is limited by its small size and non-structured assessment of Axis I diagnosis. Nonetheless, bipolar patients in this select cohort have high rates of metabolic syndrome; given this cardiovascular risk, close clinical monitoring for these parameters is recommended. While not controlling for genetics, environmental influences, and/or medical factors such as additional comorbidity and treatment duration, psychotropic drug use may confer differential risk for developing the metabolic syndrome.

PMID:
17628693
DOI:
10.1016/j.jad.2007.05.030
[Indexed for MEDLINE]
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