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J Chromatogr A. 2007 Aug 31;1162(2):167-74. Epub 2007 Jun 27.

Organic solvent nanofiltration for microfluidic purification of poly(amidoamine) dendrimers.

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Department of Chemistry, Oregon State University, Corvallis, OR 97331, USA.


A nanofiltration method has been developed in a microfluidic format for the continuous-flow pressure-driven purification of half-generation poly(amidoamine) (PAMAM) dendrimers, a family of macromolecules characterized by highly branching structures radiating from a central core, without additional solvents or buffers. An organic solvent resistant nanofiltration membrane, STARMEM 122, has been fully integrated into a hard polymer microfluidic module by transmission laser welding. The membrane was initially characterized in a bench-top test fixture to determine the solvent permeance and percent rejection of a surrogate molecule, Rhodamine B, at lower than typical operating pressures (P<7 bar). The microfluidic module then underwent similar testing at 1.4 bar with the surrogate and with the generation-0.5 PAMAM dendrimer. This approach to nanofiltration will readily interface to upstream microreactors.

[Indexed for MEDLINE]

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